The relationship between viral infection, host immune response in infants with respiratory syncytial virus (RSV) bronchiolitis and subsequent wheezing is discussed. We measured RSV-RNA load and interferon-lambda 1-3 expression in the nasopharyngeal washings from 68 infants hospitalized for RSV bronchiolitis, and wheezing was assessed 36 months after the first episode of bronchiolitis. Higher RSV-RNA load and higher interferon-lambda 2/3 levels were found in children with recurrent wheezing at 36-month follow-up.
The relationship between viral infection, host immune response in infants with respiratory syncytial virus (RSV) bronchiolitis and subsequent wheezing is discussed. We measured RSV-RNA load and interferon-λ1-3 expression in the nasopharyngeal washings from 68 infants hospitalized for RSV bronchiolitis, and wheezing was assessed 36 months after the first episode of bronchiolitis. Higher RSV-RNA load and higher interferon-λ2/3 levels were found in children with recurrent wheezing at 36-month follow-up.
Viral load in infants hospitalized for respiratory syncytial virus bronchiolitis correlates with recurrent wheezing at thirty-six-month follow-up / Nenna, Raffaella; Ferrara, Marianna; Nicolai, Ambra; Pierangeli, Alessandra; Scagnolari, Carolina; Papoff, Paola; Antonelli, Guido; Moretti, Corrado; Midulla, Fabio. - In: THE PEDIATRIC INFECTIOUS DISEASE JOURNAL. - ISSN 0891-3668. - ELETTRONICO. - 34:10(2015), pp. 1131-1132. [10.1097/INF.0000000000000825]
Viral load in infants hospitalized for respiratory syncytial virus bronchiolitis correlates with recurrent wheezing at thirty-six-month follow-up
NENNA, RAFFAELLA;FERRARA, MARIANNA;NICOLAI, AMBRA;PIERANGELI, Alessandra;SCAGNOLARI, CAROLINA;PAPOFF, PAOLA;ANTONELLI, Guido;MORETTI, Corrado;MIDULLA, Fabio
2015
Abstract
The relationship between viral infection, host immune response in infants with respiratory syncytial virus (RSV) bronchiolitis and subsequent wheezing is discussed. We measured RSV-RNA load and interferon-lambda 1-3 expression in the nasopharyngeal washings from 68 infants hospitalized for RSV bronchiolitis, and wheezing was assessed 36 months after the first episode of bronchiolitis. Higher RSV-RNA load and higher interferon-lambda 2/3 levels were found in children with recurrent wheezing at 36-month follow-up.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
